Antiprotozoal 6-substituted-5,6-dihydro-alpha-pyrones from Raimondia cf. monoica |
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Authors: | Carmona Doris Sáez Jairo Granados Hillmer Pérez Edwin Blair Silvia Angulo Alberto Figadere Bruno |
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Affiliation: | Institute of Chemistry, Universidad de Antioquia, P.O. Box 1226, Medellín-Colombia. |
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Abstract: | Dichloromethane extracts of both the roots and the leaves of Raimondia cf. monoica showed in vitro antiplasmodial and leishmanicidal activities against Plasmodium falciparum and Leishmania panamensis, respectively. Three 6-substituted 5,6-dihydro-2H-pyran-2-ones were isolated. (1) and (2) were identified as (6S)-(5'-oxohepten-1'E,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one (1) and (6R)-(5'-oxohepten-1'Z,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one (2), respectively. (-)-Arentilactone (3) was also isolated. The structure of the new compound (1) was determined by spectroscopic methods; additional spectroscopic data for (2) are reported for the first time. |
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