Modulating spontaneous brain activity using repetitive transcranial magnetic stimulation |
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| Authors: | Ysbrand D van der Werf Ernesto J Sanz-Arigita Sanne Menning and Odile A van den Heuvel |
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| Institution: | 1.Sleep and Cognition,Netherlands Institute for Neurosciences, an institute of the Royal Netherlands Academy of Arts and Sciences,Amsterdam,The Netherlands;2.Clinical Neurophysiology,VU University medical center,Amsterdam,The Netherlands;3.Dept Anatomy and Neurosciences,VU University medical center,Amsterdam,The Netherlands;4.Radiology,VU University medical center,Amsterdam,The Netherlands;5.Dept Radiology, CITA-Alzheimer Foundation,Parque Tecnológico de San Sebastián,Donostia-San Sebastián,Spain;6.Dept Psychosocial Research and Epidemiology,Netherlands Cancer Institute,Amsterdam,The Netherlands;7.Psychiatry,VU University medical center,Amsterdam,The Netherlands |
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| Abstract: | Background When no specific stimulus or task is presented, spontaneous fluctuations in brain activity occur. Brain regions showing such
coherent fluctuations are thought to form organized networks known as 'resting-state' networks, a main representation of which
is the default mode network. Spontaneous brain activity shows abnormalities in several neurological and psychiatric diseases
that may reflect disturbances of ongoing thought processes. Information about the degree to which such spontaneous brain activity
can be modulated may prove helpful in the development of treatment options. We investigated the effect of offline low-frequency
rTMS on spontaneous neural activity, as measured with fMRI, using a sequential independent-component-analysis and regression
approach to investigate local changes within the default mode network. |
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