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| An Efficient Synthesis of Cyclopeptides Bridged with Aliphatic-aryl Ether Bond | |
| 作者姓名： | ZheLIU GuiJeiTIAN DeXinWANG |
| 作者单位： | InstituteofMateriaMedica,ChineseAcademyofMedicalSciencesandPekingUnionmexticalcollege,Beijing100050 |
| 摘 要： | Based on the pseudo-dilution effect (PDE) on solid support, three cyclopeptides with an aliphatic-aryl ether bond as the bridge were synthesized via SN2 reaction between bromoacetylated at N-terminal and the phenol -OH group in C-terminal Tyr residue. All the products were obtained in good overall yields and characterized by related analytic data. |
| 关 键 词： | 苯甲酰甲基酯 合成方法 固相 分子 |
An Efficient Synthesis of Cyclopeptides Bridged with Aliphatic-aryl Ether Bond |
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| ZheLIU GuiJeiTIAN DeXinWANG.An Efficient Synthesis of Cyclopeptides Bridged with Aliphatic-aryl Ether Bond[J].Chinese Chemical Letters,2005,16(6):759-762. | |
| Authors: | Zhe LIU Gui Jei TIAN De Xin WANG? Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union medical college Beijing |
| Institution: | Zhe LIU,Gui Jei TIAN,De Xin WANG? Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union medical college,Beijing 100050 |
| Abstract: | |
| Keywords: | Intramolecular SN2 reaction cyclopeptide solid-phase organic synthesis pseudo-dilu- tion effect |
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