| Microspheres Sensor Based on Molecularly Imprinted Polymer Synthesized by Precipitation Polymerization |
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| 作者姓名： | 张朝晖 龙玉梅 刘英菊 姚守拙 |
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| 作者单位： | State Key Laboratory of Chemo/Biosensing & Chemometrics，Hunan University，Changsha，Hunan 410082，China，State Key Laboratory of Chemo/Biosensing & Chemometrics，Hunan University，Changsha，Hunan 410082，China，State Key Laboratory of Chemo/Biosensing & Chemometrics，Hunan University，Changsha，Hunan 410082，China，State Key Laboratory of Chemo/Biosensing & Chemometrics，Hunan University，Changsha，Hunan 410082，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (Nos .2 0 0 75 0 0 7and 2 0 2 75 0 0 9) |
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| 摘 要： | IntroductionSincethepiezoelectricbulkacousticwave (BAW)sen sorswereappliedinliquidphaseinthe 1980s ,manypapershavebeenreported .1,2 However,theapplicationofBAWsen sorsbasedonmasseffectislimitedbecauseoflackofthespecialselectivitytotheanalyte.Variousmethodshavebeenproposedtosolvethisproblem ,especiallytheapplicationofthebiomaterials .3Unfortunately ,theresultwasnotsogoodasexpected,duetotheinstinctdisadvantageofthebiomateri als ,e.g .,poorstability ,shortlifespan ,althoughpossess inghighselec…
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| 关 键 词： | 分子烙印聚合物 合成 聚合 微传感器 联吡啶 人尿 分析 应用 |
Microspheres Sensor Based on Molecularly Imprinted Polymer Synthesized by Precipitation Polymerization |
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| Zhang Zhao‐Hui,Long Yu‐Mei,Liu Ying‐Ju,Yao Shou‐Zhuo.Microspheres Sensor Based on Molecularly Imprinted Polymer Synthesized by Precipitation Polymerization[J].Chinese Journal of Chemistry,2003,21(5):550-555. |
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| Authors: | Zhang Zhao‐Hui Long Yu‐Mei Liu Ying‐Ju Yao Shou‐Zhuo |
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| Abstract: | A new biomimetic bulk acoustic wave sensor based on molecularly imprinted microspheres (MIM) technique was described. The sensing materials were synthesized by precipitation polymerization. By using the Scatchard analysis, the equilibrium dissociation constant KD and the apparent maximum number Qmax of the binding sites were calculated to be 3.70 mmol·L?1 and 9.11 μmol·g?1, respectively. The sensor exhibited a sensitive response to the template compound (dipyridamole) in liquid phase with a detection limit of 2 × 10–9 mol· L?1. The recoveries of the sensor were 95.1%‐105.4%. Studies presented in this paper show that the stability of this sensor is excellent. The sensor has been applied successfully to the determination of dipyridamole in human urine. |
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| Keywords: | microspheres sensor molecularly imprinted polymer dipyridamole precipitation polymerization |
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