快速溶剂萃取-气相色谱/质谱法分析血液中的甲卡西酮

建立血液中甲卡西酮快速溶剂萃取（ASE）-气相色谱/质谱（GC/ MS）分析的新方法. 通过优化 ASE 的萃取条件（溶剂、温度及时间）,对血液中的甲卡西酮进行有效提取,之后用 GC/ MS 进行定性、定量分析. 方法检出限为0. 02 mg / L,定量限为0. 1 mg / L. 血液中甲卡西酮在0. 5、1. 0 和2. 0 mg / L 3 个添加水平的平均回收率在96. 70% ~99. 27%之间,甲卡西酮在0. 1 ~ 50 mg / L 的浓度范围内线性良好. 方法快速、简便、高效且操作自动化,适用于血液中甲卡西酮的检验鉴定.

Analysis of Methcathinone in Blood by GC/MS with Accelerated Solvent Extraction

A new method of GC/MS coupled with accelerated solvent extraction(ASE) to determined methcathinone in blood sample is developed. Methcathinone were extracted by the ASE method using optimized parameters(solvent,temperature and time), the concentrated eluate was analyzed with GC/MS.The detection limit of the method is 0.02 mg/L, and the quantitative limit is 0.1 mg/L. The recoveries of methcathinone with three added levels in the blood were 96.70%~99.27%. A good linear relationship was obtained at the range of 0.1~50 mg/L. The method is rapid, simple, convenient and effective, and the proposed method can be used to extract methcathinone in biological specimens due to its superiority comparing with other traditional extraction methods.