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| A Convenient Method for the Stereoselective Synthesis of 7αHydroxycholesterol | |
| 作者姓名： | Ling Jie GAO and Tian Zeng ZHAO Guang Dian HAN(The Institute of Chemistry Henan Academy of Sciences Zhengzhou 450002)(Institute of Materia Medica Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100050) |
| 作者单位： | Ling Jie GAO and Tian Zeng ZHAO; Guang Dian HAN(The Institute of Chemistry，Henan Academy of Sciences，Zhengzhou，450002)(Institute of Materia Medica，Peking Union Medical College，Chinese Academy of Medical Sciences，Beijing 100050) |
| 摘 要： | 7-Hydroxyderivativesofcholesteroldisplayawidevarietyofbiologicalactivities'-',mostofwhicharerelatedtothephysiologicalcontrolofcholesterolbiosynthesisandantitumoractivity.Inearlyreports',the7-hydroxycholesterolswerepreparedbythesequenceofacetylation,allylicchromicoxidation,andhydridereduction.Generally,theproductisamixtureof7a-and76-epimerswhichisdifficulttobeseparated.V.Kumaretal5improvedthisprocedurebyusingstereospecificreducingreagentsinsteadofthesimplehydride.7a-and7o-epimerscouldbeobtained… |
| 关 键 词： | 7α-hyrdoxycholesterol cholesteryl acetate stereoselective hydroxylation |
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