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A Convenient Method for the Stereoselective Synthesis of 7αHydroxycholesterol

作者姓名：	Ling Jie GAO and Tian Zeng ZHAO Guang Dian HAN

作者单位：	Ling Jie GAO and Tian Zeng ZHAO; Guang Dian HAN(The Institute of Chemistry，Henan Academy of Sciences，Zhengzhou，450002)(Institute of Materia Medica，Peking Union Medical College，Chinese Academy of Medical Sciences，Beijing 100050)

摘要：	7-Hydroxyderivativesofcholesteroldisplayawidevarietyofbiologicalactivities'-',mostofwhicharerelatedtothephysiologicalcontrolofcholesterolbiosynthesisandantitumoractivity.Inearlyreports',the7-hydroxycholesterolswerepreparedbythesequenceofacetylation,allylicchromicoxidation,andhydridereduction.Generally,theproductisamixtureof7a-and76-epimerswhichisdifficulttobeseparated.V.Kumaretal5improvedthisprocedurebyusingstereospecificreducingreagentsinsteadofthesimplehydride.7a-and7o-epimerscouldbeobtained…
关键词：	7α-hyrdoxycholesterol cholesteryl acetate stereoselective hydroxylation
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