Synthesis of chirally pure 2,5-disubstituted diketopiperazines derived from trisubstituted phenylalanines |
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Authors: | Satyavijayan Narasimhan Danthi Ronald A. Hill |
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Abstract: | Some new chirally pure 2,5-substituted diketopiperazines were synthesized starting from 2-methoxybenzyl alcohol. This multistep synthesis proceeds through the enzymatic synthesis of chirally pure amino acids, protection and dipeptide coupling, cyclization of dipeptide ester formates, and nitration of the resulting diketopiperazines. |
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