Mass spectrometric behaviour of 1-imino-substituted pyrazolo[1,2-a]-[1,2,4]triazoles under electron and chemical ionization |
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Authors: | Karoliina Joutsiniemi Pirjo Vainiotalo Olaf Morgenstern Anke Klemann |
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Abstract: | The spectra of five pharmacologically interesting substituted pyrazolo1,2-a]1,2,4]triazole hydroiodides were measured under electron and chemical ionization. In the electron ionization spectra, in addition to the intense molecular ion peak of the free base (M+*), there was also a relatively intense molecular ion peak of the hydroiodide form, which is unusual since the hydroiodides are rarely so stable. The phenylimino and phenylamino substituents of the triazole ring affected the fragmentation behaviour of the compounds very much. The chemical ionization reagent gases used in this work were methane, isobutane, deuterated ammonia and acetone. In all the cases practically only M+H]+ ions were observed, the only exception being acetone which also gave rise to intense M+C2H3O]+ and M+C3H7O]+ adduct ions. None of the reagent gases used was able to cause any fragmentation. |
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