Chemistry of functionalized benzazepines. 5. Synthesis and chemical transformation of the 1,2,4,5-tetrahydrospiro-[3H-2-benzazepine-3,1′-cycloalkanes] |
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| Authors: | Vladimir Kouznetsov,Palma R. Alirio,Sandra Salas,Leonor Y. Vargas,Jairo Ren Martinez,Fedor Zubkov,Alexei Varlamov |
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| Affiliation: | Vladimir Kouznetsov,Palma R. Alirio,Sandra Salas,Leonor Y. Vargas,Jairo René Martinez,Fedor Zubkov,Alexei Varlamov |
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| Abstract: | The synthesis of new spiro derivatives of tetrahydro-2-benzazepine was accomplished and their nitration, bromination, allylation, acetylation, formylation and oxidation reactions were studied. Nitration and bromi-nation of 5-methyl(1,5-dimethyl)-1,2,4,5-tetrahydrospiro[3H-2-benzazepine-3,1-cycloalkane] took place regioselectively on position C-8 of the phenyl ring. A nitrone was obtained for the first time in the title series. The structures of the compounds were established by ir and nmr spcctroscopy. |
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