An improved process of separation of R- and S-timolol |
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Authors: | Erika V rkonyi-Schlovicsk ,K lm n Tak cs,Istv n Hermecz |
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Affiliation: | Erika Várkonyi-Schlovicskó,Kálmán Takács,István Hermecz |
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Abstract: | Diastereomeric timolol tartrates 4 are obtained in a one-pot synthesis from the racemic base 2 and optically active O,O-diacetyl- or O,O-dibenzoyltartaric anhydrides 3 , as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4 leads to timolol in high yield and optical purity. |
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