Preparation of ortho-aryl-benzaldehyde derivatives via free-radical ipso-substitution of an amidomethyl group

Preparation of 2-biarylcarbaldehydes using an intramolecular free-radical ispo-substitution is described. The two aryl moieties to be coupled are pre-associated using a glycolamide derivative. An unusual amidomethyl leaving group was successfully employed in this process.