| 1-异烟酰基-4-芳酰基氨基硫脲化合物的研究 |
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| 引用本文： | 张自义,陈立民. 1-异烟酰基-4-芳酰基氨基硫脲化合物的研究[J]. 高等学校化学学报, 1981, 2(1): 50 |
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| 作者姓名： | 张自义 陈立民 |
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| 作者单位： | 兰州大学化学系 |
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| 摘 要： | 进一步研究了卤代芳酰异硫氰与异烟酰肼反应,制得一系列1-异烟酰基-4-卤代芳酰基氨基硫脲,并观察了这些新药物的抗结核菌性能,其中以1-异烟酰基-4-对碘苯甲酰基-氨基硫脲抗结核菌作用最强。
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| 收稿时间： | 1979-12-25 |
A STUDY OF 1-ISONICOTINOYL-4-AROYLTHIOSEMICARBAZIDES COMPOUNDS |
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| Zhang Ziyi,Chen Limin. A STUDY OF 1-ISONICOTINOYL-4-AROYLTHIOSEMICARBAZIDES COMPOUNDS[J]. Chemical Research In Chinese Universities, 1981, 2(1): 50 |
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| Authors: | Zhang Ziyi Chen Limin |
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| Affiliation: | Department of Chemistry, Lanzhou University, Lanzhou |
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| Abstract: | For the purpose of studying the relation between molecular structure and tuberculostatic activity in acylthiosemicarbazide group, some new derivatives of thiosemicarbazide such as 1-isonicotinoyl-4-halogen-aroyl-thiosemicarbazides have been synthesized.These new compounds ware prepared by developing the reaction of the halogen aroylisothiocyanate with isonicotinoyl hydrazide In acetone, acetonitrile or djoxane in yield of 50-80%. |
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