Abstract: | A preparative method of synthesis of 2-substituted thieno2,3-d]pyrimidin-4-ones involving deamination of the corresponding 3-amino derivatives, by sodium nitrite in acidic medium is proposed. A possible reaction mechanism is considered.A. L. Mndzhoyan Institute of Fine Organic Chemistry. Academy of Sciences of the Republic of Armenia, Erevan 375014 Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 941–944, July, 1999. |