Toward an artificial aldolase |
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Authors: | Font Daniel Sayalero Sonia Bastero Amaia Jimeno Ciril Pericàs Miquel A |
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Affiliation: | Institute of Chemical Research of Catalonia (ICIQ), Av. Pa?sos Catalans, 16, E-43007 Tarragona, Spain. |
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Abstract: | A new functional polymer where proline is bonded to polystyrene through a 1,2,3-triazole linker depicts characteristics targeted for an artificial aldolase. In spite of the hydrophobicity of the polymer backbone, the resin swells in water with building of an aqueous microenvironment. This property, arising from the formation of a hydrogen-bond network connecting the proline and 1,2,3-triazole fragments, is translated into a very high catalytic activity and enantioselectivity toward direct aldol reactions in water. |
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