Impact of C-Terminal Chemistry on Self-Assembled Morphology of Guanosine Containing Nucleopeptides |
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Authors: | Katherine Boback,Katherine Bacchi,Sarah O’ Neill,Samantha Brown,Jovelt Dorsainvil,Jillian E. Smith-Carpenter |
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Affiliation: | Department of Chemistry and Biochemistry, Fairfield University, 1073 N. Benson Rd, Fairfield, CT 06824, USA; (K.B.); (K.B.); (S.O.); (S.B.); (J.D.) |
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Abstract: | Herein, we report the design and characterization of guanosine-containing self-assembling nucleopeptides that form nanosheets and nanofibers. Through spectroscopy and microscopy analysis, we propose that the peptide component of the nucleopeptide drives the assembly into β-sheet structures with hydrogen-bonded guanosine forming additional secondary structures cooperatively within the peptide framework. Interestingly, the distinct supramolecular morphologies are driven not by metal cation responsiveness common to guanine-based materials, but by the C-terminal peptide chemistry. This work highlights the structural diversity of self-assembling nucleopeptides and will help advance the development of applications for these supramolecular guanosine-containing nucleopeptides. |
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Keywords: | nucleopeptide self-assembly guanosine G-quartet |
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