Preparation,characterization and biodistribution of the 99mTc-salicylidenediamine-N-dione complex |
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Authors: | M. Javed I. U. Khan M. Naeem S. Asghar H. Naseer M. S. Iqbal J. Anwar |
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Affiliation: | (1) Institute of Nuclear Medicine and Oncology (INMOL), Wahdat Road, P. O. Box 10068, Lahore, 54600, Pakistan;(2) Department of Pharmacy, University of Sargodha, Sargodha, Pakistan;(3) Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan |
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Abstract: | A tetradentate set of N2O2 salicylaldehyde-amine-N-dione Schiff base was prepared by condensation with salicylaldehyde, ethylenediamine, 2,4-dione and reduction with NaBH4. The ligand system was characterized by 1H-NMR and FT-IR spectroscopy and HPLC. Radiolabeling studies of the 99mTc-complex were performed using stannous ions as the reducing agent. The purity of the complex was determined by ascending solvent system on paper chromatography and instant thin-layer chromatography (ITLC). The yield of the complex was >90%. Biodistribution of the 99mTc-complex of the precursor was studied in rabbits. A significant uptake and retention of injected activity was observed in the liver and cleared through the bladder. A faint activity was also observed in kidneys. These results indicate that the proposed system may be suitable for development of a liver/spleen imaging agent for future clinical applications. |
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