Synthesis of 5-substituted 3-[5-(2,5-dimethylphenyl)-1,2-oxazol-3-yl]-1,2,4-oxadiazoles |
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| Authors: | V I Potkin S K Petkevich P V Kurman |
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| Institution: | (1) Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, ul. Surganova 13, Minsk, 220072, Belarus |
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| Abstract: | 5-(2,5-Dimethylphenyl)-1,2-oxazole-3-carbaldehyde oxime reacted with acetic anhydride in pyridine to give 5-(2,5-dimethylphenyl)-1,2-oxazole-3-carbonitrile which was converted into the corresponding amide oxime by treatment with hydroxylamine. O-Acyl derivatives of N′-hydroxy-5-(2,5-dimethylphenyl)-1,2-oxazole-3-carboximidamide underwent heterocyclization into 5-substituted 3-5-(2,5-dimethylphenyl)-1,2-oxazol-3-yl]-1,2,4-oxadiazoles on heating in acetic acid. |
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