Evaluation of soot particles of biomass fuels with endocrine-modulating activity in yeast-based bioassay |
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Authors: | Jingxian?Wang Ping?Xie Antonius?Kettrup Email author" target="_blank">Karl-Werner?SchrammEmail author |
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Institution: | (1) Donghu Experimental Station of the Lake Ecosystems, The State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, PR China;(2) GSF-National Research Centre of Environment and Health, Institute of Ecological Chemistry, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany;(3) Lehrstuhl für Ökologische Chemie und Umweltanalytik, Technische Universität München, 85350 Freising, Weihenstephan, Germany |
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Abstract: | Exposure to indoor air pollution (IAP) from the combustion of biomass fuels is an important cause of morbidity and mortality in developing countries. In the work discussed in this paper we evaluated the endocrine activity of soot particles from biomass fuels by using yeast bioassay. These pollutants could have -galactosidase activity with a relative potency (RP) about 10–7–10–9 that of estradiol. Soot particles from wood and straw combustion only partially induced -galactosidase activity whereas others produced fully inductive activity in the yeast assay system. These pollutants did not have estrogen antagonist and progesterone agonist activity within the defined concentration range. However, these pollutants require 2–4 orders of magnitude higher IC50 to inhibit the activity of progesterone in a similar dose-response manner to mifepristone. We therefore propose that the endocrine activity of some environmental pollutants may be because of inhibition of the progesterone receptor (hPR). GC–MS results showed that substituted polycyclic aromatic hydrocarbon (PAH) compounds, substituted phenolic compounds and derivatives, aromatic carbonyl compounds, and phytosteroids in these soot particles may be mimicking endogenous hormones. |
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Keywords: | Biomass fuel Soot Endocrine modulating disrupter Yeast bioassay Reproductive health |
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