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Synthesis of 2-aryl-4-phenyl-5-trifluoromethylimidazoles
Authors:Joseph G. Lombardino
Abstract:Several 2-aryl-4-phenyl-5-trifluoromethylimidazoles have been made from the previously unknown 1-phenyl-3,3,3-trifluoro-1,2-propanedione monohdyrate. One analog, 4-phenyl-2,5-bis(trifluoromethyl)imidazole, is quite acidic, exhibiting pKa 8.1.
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