Synthesis of 2-aryl-4-phenyl-5-trifluoromethylimidazoles |
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Authors: | Joseph G. Lombardino |
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Abstract: | Several 2-aryl-4-phenyl-5-trifluoromethylimidazoles have been made from the previously unknown 1-phenyl-3,3,3-trifluoro-1,2-propanedione monohdyrate. One analog, 4-phenyl-2,5-bis(trifluoromethyl)imidazole, is quite acidic, exhibiting pKa 8.1. |
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