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Mannich-type reactions of an isobasic isoquinoline |
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| Authors: | K Lm n Iiars nyi,P l Kiss,Dezs Korbonits |
| Affiliation: | KáLmán Iiarsányi,Pál Kiss,Dezsö Korbonits |
| Abstract: | Base catalyzed reaction of 1-cyanomethylene-6,7-dimethoxy-1,2,3,4-tetrahyroisoquinoline (I) with 2 moles of formaldehyde gave rise to the 1,3-oxazino[4,3-a ]isoquinoline ring system (III). Reaction of I with a primary amine and 2 moles of formaldehyde gave pyrimido[ 6,1-a ]-isoquinoline (VI). |
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