| Biosynthesis of Monoterpenoid Indole Alkaloid Ajmaline Catalyzed by Novel Reductases |
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| 引用本文： | GAO Shu-juan Gerald von Schumann Joachim Stoeckigt. Biosynthesis of Monoterpenoid Indole Alkaloid Ajmaline Catalyzed by Novel Reductases[J]. 高等学校化学研究, 2006, 22(2): 267-269. DOI: 10.1016/S1005-9040(06)60095-0 |
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| 作者姓名： | GAO Shu-juan Gerald von Schumann Joachim Stoeckigt |
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| 作者单位： | Department of Pharmaceutical Biology Institute of Pharmacy Johannes Gutenberg University Staudinger Weg 5 D-55099 Mainz Germany，Department of Pharmaceutical Biology Institute of Pharmacy Johannes Gutenberg University Staudinger Weg 5 D-55099 Mainz Germany |
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| 基金项目： | Supported by a Grant of the Deutsche Forschungsgemeinschaft （ DFG, Bonn Bad-Godesberg）, the Fonds der Chemischen Industrie （Frankfurt/Main） and the BMBF（ Bonn）, CHN 96/303. S.Acknowledgements Gao acknowledges a scholarship provided by the DLR, Internationales BUro des BMBF. |
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| 摘 要： | Introduction OneofthemajorrootalkaloidsoftheIndianme dicinalplantRauvolfiaserpenlinaBenth.exKurzis namedajmaline.Theenzymaticbiosynthesisofthisal kaloidhasbeenstudiedforalongtimebyourgroup[1].Asaresult,abiosyntheticpathwayhasbeenestab lished,inwhichabout1…
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| 关 键 词： | 生物合成 单萜类化合物 吲哚 生物碱 还原酶 催化 |
| 文章编号： | 1005-9040（2006）-02-267-03 |
| 收稿时间： | 2005-12-20 |
Biosynthesis of Monoterpenoid Indole Alkaloid Ajmaline Catalyzed by Novel Reductases |
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| Shu-juan GAO, Gerald von Schumann,Joachim St,#xf;ckigt. Biosynthesis of Monoterpenoid Indole Alkaloid Ajmaline Catalyzed by Novel Reductases[J]. Chemical Research in Chinese University, 2006, 22(2): 267-269. DOI: 10.1016/S1005-9040(06)60095-0 |
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| Authors: | Shu-juan GAO, Gerald von Schumann,Joachim St ckigt |
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| Affiliation: | aDepartment of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University, Staudinger Weg 5, D-55099 Mainz, Germany |
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| Abstract: | One of the major root alkaloids of the Indian medicinal plant Rauvolfia serpenlina Benth. ex Kurz is named ajmaline. The enzymatic biosynthesis of this alkaloid has been studied for a long time by our group [1]. As a result, a biosynthetic pathway has been established, in which about 10 enzymes participate, several of them belonging to the group of NADPH-dependent reductases. Started with the biosynthetic precursors tryptamine and secologanin, at least five reductions are involved in the biosynthetic route to procure ajmaline (Fig.1). |
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| Keywords: | Biosynthesis Alkaloid Reductase Ajmaline |
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