Enantio- and diastereocontrolled total synthesis of (+)-boronolide |
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Authors: | Kumar Pradeep Naidu S Vasudeva |
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Institution: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India. pk.tripathi@ncl.res.in |
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Abstract: | An efficient stereoselective total synthesis of (+)-boronolide from valeraldehyde is described. The key steps include a Sharpless asymmetric hydroxylation, a chelation-controlled vinyl Grignard reaction followed by a Sharpless asymmetric epoxidation, hydrolytic kinetic resolution, and a ring-closing metathesis. |
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