A Novel ‘Domino‐Click Approach’ to Unsymmetrical Bis‐1H‐1,2,3‐triazoles |
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| Authors: | Abid?H Banday Bhupinder?S Arora Mohammed?S Alam Halmuthur?M?Sampath Kumar |
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| Affiliation: | 1. Synthetic Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu‐Tawi 180001, India (fax: 0191‐2569333);2. Department of Chemistry, Jamia Hamdard University, New Delhi‐110062, India |
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| Abstract: | Aryl azides 1 were treated with allenylmagnesium bromide ( 2 ) to generate 1,5‐disubstituted butynyl‐1H‐1,2,3‐triazoles 3 in a domino fashion, which upon CuI‐catalyzed 1,3‐dipolar cycloaddition with aryl azides 4 afforded novel bis‐1H‐1,2,3‐triazoles 5 in quantitative yields (Scheme 1 and Table). |
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| Keywords: | ‘ Click chemistry’ 1H‐1 2 3‐Triazoles Cycloadditions Allenylmagnesium bromide |
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