Efficient Conjugate Addition of 1H‐Indoles to Electron‐Deficient Olefins Catalyzed by Silica‐Supported Sodium Hydrogen Sulfate (NaHSO4 ⋅ SiO2) |
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| Authors: | Biswanath Das Nikhil Chowdhury K. Damodar K. Ravinder Reddy |
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| Affiliation: | 1. Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500 007, India, (phone: +?91‐40‐7193434;2. fax: +?91‐40‐7160512) |
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| Abstract: | A simple, mild, rapid, and highly efficient method for the conjugate addition of 1H‐indoles to electron‐deficient olefins has been developed using NaHSO4 ? SiO2 as heterogeneous catalyst. The conversion proceeds at room temperature, and the corresponding Michael adducts are formed in good‐to‐excellent yields. |
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| Keywords: | Conjugate addition reaction 1H‐Indoles Olefins, electron‐deficient Michael adducts Sodium hydrogen sulfate, silica‐supported Catalysis |
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