Biomimetic Model of Coenzyme B12: Aquabis(ethane‐1,2‐diamine‐κN,κN′)ethylcobalt(III) – Its Kinetic and Binding Studies with Imidazoles and Amino Acids and Interactions with CT DNA |
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| Authors: | Ponuganti Pallavi Penumaka Nagababu Sirasani Satyanarayana |
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| Institution: | Department of Chemistry, Osmania University, Hyderabad, 500?007, India, (phone: +91‐40‐27682337) |
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| Abstract: | Pseudo‐first‐order reaction kinetics and binding studies of trans‐Co(en)2(Et)H2O] complex with 1H‐imidazole, substituted 1H‐imidazoles, histidine, histamine, glycine and glycine ethyl ester were investigated by means of spectrophotometric techniques. Equilibrium constants were determined as a function of pH at 25°. Binding and kinetic studies were correlated to basicity and steric hindrance. From the equilibrium data, it was found that the entering nucleophile is participating in the transition state, an Id mechanism is proposed. The effect of the incoming ligands on the complex was studied by molecular mechanics. The interaction of trans‐Co(en)2(Et)H2O] with CT DNA was studied spectrophotometrically. |
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| Keywords: | Vitamins Biomimetic reactions Coenzyme B12 1H‐Imidazoles Cobalt complexes Calf thymus DNA DNA |
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