Sesquiterpene Lactones from Anthemis melanolepis |
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| Authors: | Vasiliki Saroglou Anastasia Karioti Jörg Heilmann Zacharias Kypriotakis Helen Skaltsa |
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| Affiliation: | 1. Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71 Athens, Greece, (phone/fax: +?30‐210‐7274593);2. Institute of Pharmacy, Department of Pharmaceutical Biology, University of Regensburg, Universit?tsstrasse 31, 93053 Regensburg, Germany;3. Technological Education Institute, School of Agricultural Production, Laboratory of Taxonomy and Management of Wild Flora, Stavromenos P.?O. Box 140, 71110 Heraclion‐Crete, Greece |
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| Abstract: | From the aerial parts of A. melanolepis, two new sesquiterpene lactones, melanolepin B ( = 1α,4β,8α‐trihydroxyeudesm‐11(13)‐en‐12,6α‐olide; 1 ) and melanolepin C (= 1α,10β‐epoxy‐8β‐hydroxygermacra‐4(15),11(13)‐dien‐12,6α‐olide; 2 ), were isolated, together with four known compounds, desacetyllaurenobiolide, dentatin A, taraxasterol, and (3S,5R)‐loliolide. Compound 1 was found to have the rare cis‐fused eudesmane skeleton. The structures of the isolated compounds were established by means of NMR (1H, 1H‐COSY, 1H,13C‐HSQC, HMBC, NOESY) and MS analyses. |
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| Keywords: | Anthemis melanolepis Eudesmane sesquiterpenes Sesquiterpene lactones Melanolepins B and C |
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