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Synthesis of Nicotinamide Adenine Dinucleotide (NAD) Analogues with a Sugar Modified Nicotinamide Moiety |
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| Authors: | Natasha Goulioukina Johny Wehbe Damien Marchand Roger Busson Eveline Lescrinier Dieter Heindl Piet Herdewijn |
| Institution: | 1. Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Minderbroedersstraat 10, B‐3000 Leuven, (phone: +32?16?337387;2. fax: +32?16?337340);3. Roche Diagnostics GmbH, Nonnenwald 2, D‐82372 Penzberg |
| Abstract: | The synthesis of nicotinamide adenine dinucleotide (NAD) analogues in which the ribose unit of the nicotinamide moiety is replaced by a hexitol, altritol, and cyclohexenyl sugar mimic is described. |
| Keywords: | Nicotinamide adenine dinucleotide (NAD) Hexitol nucleosides Nucleosides Altritol nucleosides Cyclohexenyl nucleosides |