Quantitative Online Detection of Low‐Concentrated Drugs via a SERS Microfluidic System |
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| Authors: | Katrin R Ackermann Thomas Henkel Dr Jürgen Popp Dr |
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| Institution: | 1. Institute of Physical Chemistry, Friedrich‐Schiller‐University Jena, Helmholtzweg 4, 07743 Jena, Germany;2. Institute of Photonic Technology, Albert‐Einstein‐Str. 9, 07745 Jena, Germany |
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| Abstract: | Herein, quantitative online monitoring of concentration fluctuations of different interesting drugs, namely, the phenothiazine promethazine as well as the anti‐cancer agent mitoxantrone via surface enhanced Raman scattering assay based on a microfluidic device is demonstrated. With the applied liquid/liquid two‐phase‐segmented flow system we succeed in preventing the adhesion of nanoparticle aggregates to the channel walls which is necessary for a quantitative analysis. Even after repeated cycles no carry‐over due to sedimentation of colloid particles is observed. To the best of our knowledge these are the first measurements applying a combination of a microfluidic device with SERS detection for quantitative online monitoring of fluctuations in drug concentrations over hours without use of aggressive chemicals for rinsing the chip surfaces prior to each measurement. |
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| Keywords: | colloids drug analysis lab‐on‐a‐chip microfluidics Raman spectroscopy |
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