非电活性分子的活体电化学分析进展

发展非电活性分子的活体电化学分析方法，对于解析这些物质在生理过程和病理过程中的作用具有重要研究意义. 本综述从三种分析策略出发，简要介绍了最近活体电化学传感器的研究进展：1）设计和筛选高选择性配体，通过将特异性的化学反应转换成电化学信号，发展了新型的非电活性分子的活体分析；2）利用微型孔道里的整流效应，结合特异性配体，建立了非电活性分子的新型分析平台；3）结合微电极阵列技术及同时分析多种输出信号的新型分析模式，实现活体中的多种非电活性物质的同时分析.

Advanced Electrochemical Strategy for in Vivo Detection of Electrochemically Inactive Molecules

Development of efficient electrochemical strategies for in vivo analysis of electrochemically inactive molecules in brain is significant for understanding and studying their molecular mechanism and roles playing in brain and brain diseases. This review gives a brief introduction on the advanced in vivo electrochemical sensor for detection of non-redox active molecules from three aspects: 1) The selection and design of specific molecules are highly desirable to develop electrochemical sensors with high selectivity for measuring electrochemical inactive molecules through converting specific chemical reaction involved by target to electric signal; 2) The analysis based on ion current rectification occurred at spatial confined micro-interface provides a promising alternative way to realize in vivo monitoring of chemical inert molecules. 3) Integration of electrochemical sensors onto electrode arrays and new concept of dual signal outputs establish a flexible and promising approach for the further analysis of multiple species. At last, some perspectives are highlighted in the further development of the efficient electrochemical platform for in vivo detection of electrochemical inactive ions.