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A facile regioselective synthesis of (5‐amino‐4‐cyano‐1h‐imidazol‐1‐yl) benzoic acids
Authors:Síria A Barros  M Sameiro T Gonçalves  Ana M F Oliveira‐Campos  Fernanda R P Proença
Institution:1. Centre of Chemistry, University of Minho, Gualtar, P‐4710‐057 Braga, Portugal, Tel +351253604386;2. Fax + 351253678983
Abstract: chemical structure image A simple and efficient method was developped for the synthesis of 3‐(5‐amino‐4‐cyano‐1H‐imidazol‐1‐yl)‐4‐substituted benzoic acids 3 . These compounds were isolated by intramolecular cyclisation of the corresponding 3‐{(Z)‐2‐amino‐1,2‐dicyano‐vinyl]amino}methyleneaminobenzoic acids in the presence of base.
Keywords:
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