Four New Briarane Diterpenoids from the Gorgonian Coral Junceella fragilis |
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| Authors: | Ya‐Ching Shen Yu‐Hui Chen Tsong‐Long Hwang Jih‐Hwa Guh Ashraf?Taha Khalil |
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| Institution: | 1. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China, (phone: +886‐02‐3123456 (ext 2226);2. fax: +886‐02‐23919098);3. Institute of Marine Biotechnology and Resources, National Sun Yat‐sen University, 70 Lien‐Hai Road, Kaohsiung, Taiwan 80424, Republic of China;4. Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan, Republic of China |
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| Abstract: | Chemical investigation of the gorgonian coral Junceella fragilis, collected by scuba diving in Taiwan, resulted in the isolation of four new briarane‐type diterpenoids, frajunolides A–D ( 1 – 4 ), along with three known briaranes. Their structures were elucidated on the basis of spectroscopic studies, especially 1‐ and 2D‐NMR as well as HR‐MS experiments. The inhibitory effect of all isolated metabolites towards superoxide‐anion generation and elastase release by human neutrophils in response to formylmethionyl‐leucyl‐phenylalanine/dihydrocytochalasin B (FMLP/CB) was evaluated. |
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| Keywords: | Junceella fragilis Briarane diterpenoids Diterpenoids Frajunolides A – D |
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