Chemical Constituents of the Endophytic Fungal Strain Phomopsis sp. NXZ‐05 of Camptotheca acuminata |
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| Authors: | Qifang Tan Xuefen Yan Xiang Lin Yaojian Huang Zhonghui Zheng Siyang Song Chunhua Lu Yuemao Shen |
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| Affiliation: | 1. Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering;2. , Xiamen Engineering Research Center of Marine Microbial Drug Discovery;3. Fujian Laboratory of Pharmaceutical Engineering;4. School of Life Sciences, Xiamen University, No.?422 South Siming Road, Xiamen, Fujian 361005, P.?R. China, (phone: +86‐592‐2184180;5. fax: +86‐592‐2181772) |
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| Abstract: | From the endophytic fungal strain Phomopsis sp. NXZ‐05 of Camptotheca acuminata Decne . (Nyssaceae), six new compounds were isolated, including the ten‐membered macrolides 1 – 4 and their (known) parent compound multiplolide A ( 7 ), as well as a new unsaturated fatty acid, (4E)‐6,7,9‐trihydroxydec‐4‐enoic acid ( 5 ) and its methyl ester 6 . Their structures were elucidated by spectroscopic and mass‐spectrometric analyses, including 1D‐ and 2D‐NMR experiments and HR‐ESI‐MS, and their biological activities were elucidated. |
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| Keywords: | Endophytic fungus Phomopsis sp. NXZ‐05 Camptotheca acuminata Macrolides Decenoic acid Multiplolides |
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