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A Novel Synthesis of Highly Substituted Perhydropyrrolizines,Perhydroindolizines, and Pyrrolidines: Inhibition of the Peptidyl‐Prolyl cis/trans Isomerase (PPIase) Pin1 |
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| Authors: | Romain Siegrist Martina Zürcher Corinne Baumgartner Paul Seiler François Diederich Sebastian Daum Gunter Fischer Christian Klein Markus Dangl Manfred Schwaiger |
| Institution: | 1. Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, H?nggerberg, HCI, CH‐8093 Zürich;2. Max‐Planck‐Forschungsstelle für Enzymologie der Proteinfaltung, Weinbergweg?22, D‐06120 Halle (Saale);3. Roche Diagnostics GmbH, Nonnenwald?2, D‐82377 Penzberg |
| Abstract: | |
| Keywords: | Pin1 Enzyme inhibitors Cancer therapy Pyrrolizine perhydro‐ Indolizine perhydro‐ Pyrrolidine NMR Spectroscopy Inhibitors |