Withanolides from Withania adpressa |
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| Authors: | Lalla Hasna Abdeljebbar Munir Humam Philippe Christen Damien Jeannerat Bruno Vitorge Saaid Amzazi Abdelaziz Benjouad Kurt Hostettmann Khalid Bekkouche |
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| Affiliation: | 1. Laboratoire de Biochimie‐Immunologie, Faculté des Sciences, Département de Biologie, Université Mohammed V, Avenue Ibn Batouta, Rabat, Morocco;2. Laboratoire Biotechnologies, Protection et Valorisation des Ressources Végétales, Groupe Phytochimie et Pharmacologie des Plantes Aromatiques et Médicinales, Faculté des Sciences‐Semlalia, BP, 2390, Marrakech, Morocco;3. Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4 (phone: +41‐22‐3796561;4. fax: +41‐22‐3793399);5. Department of Organic Chemistry, University of Geneva, Quai Ernest‐Ansermet 30, CH‐1211 Geneva 4 |
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| Abstract: | From the leaves of Withania adpressa, a plant endemic to Sahara of Morocco and Algeria, the novel steroidal lactone (22R)‐14α,15α,17β,20β‐tetrahydroxy‐1‐oxowitha‐2,5,24‐trien‐26,22‐olide (= (15S,17S)‐14,15,17,20‐tetrahydroxy‐22,26‐epoxyergosta‐2,5,24‐triene‐1,26‐dione; 1 ), was isolated, along with three known compounds, withanolides F ( 2 ), J ( 3 ), and oleanolic acid. Their structures were mainly solved by in‐depth 1D‐ and 2D‐NMR (including ADEQUATE) experiments, as well as by HR‐MS analyses and chemical evidence. |
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| Keywords: | Withania adpressa Withanolides Lactones Steroids |
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