Surface Stabilization of Diblock PEG‐PLGA Micelles by Polymerization of N‐Vinyl‐2‐pyrrolidone |
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Authors: | Hong Kee Kim Tae Gwan Park |
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Abstract: | This paper presents a new approach to improving the physical stability of biodegradable poly‐(ethylene glycol)‐block‐poly[(DL ‐lactic acid)‐co‐(glycolic acid)] (PEG‐PLGA) micelles. A hydroxyl‐terminated PEG monomethacrylate (PEGmer) macroinitiator was used to prepare a methacrylate‐end‐capped PEG‐PLGA diblock copolymer by the ring‐opening polymerization of D ,L ‐lactide and glycolide. The surface‐exposed methacrylate groups in the shell layer of the micelles can be polymerized with N‐vinyl‐2‐pyrrolidone. The resulting micelles show substantially enhanced stability. |
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Keywords: | biodegradable micelles PEG PLGA |
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