Isothermal Titration Calorimetry of Molecularly Imprinted Polymer Nanospheres |
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Authors: | Achim Weber,Melanie Dettling,Herwig Brunner,Gü nter E. M. Tovar |
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Abstract: | Ultrasensitive isothermal titration calorimetry was used to generate thermodynamic data to assess the binding properties of molecularly imprinted polymer microgels. Microgels were imprinted using L ‐boc‐phenylalanine anilide (L ‐BFA) and then utilized in binding experiments with a variety of probe molecules, structurally closely related to the template molecule. Significant differences were observed between the binding enthalpy of the original template L ‐BFA and those of D ‐BFA, L ‐boc‐phenylalanine, L ‐boc‐tryptophane, and L ‐boc‐tyrosine. |
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Keywords: | colloids microgels molecular recognition templates thermodynamics |
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