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Synthesis of α‐Cyclodextrin‐Conjugated Poly(ε‐lysine)s and Their Inclusion Complexation Behavior
Authors:Kang Moo Huh  Hajime Tomita  Won Kyu Lee  Tooru Ooya  Nobuhiko Yui
Abstract:Novel functional polymers utilizing specific host/guest interactions were designed by introducing α‐CD host molecules into poly(ε‐lysine) chains as side groups. An interesting phase separation was observed as a result of the inclusion complexation between the polymeric host and 3‐(trimethylsilyl)propionic acid as a model guest in aqueous media. This water‐soluble polymeric host would be useful for various applications, particularly drug delivery, due to its biodegradability, low toxicity, and unique functionality represented as a complexation‐induced phase separation.
Keywords:cyclodextrins  host‐guest systems  inclusion chemistry  phase separation
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