| Antituberculosis and cytotoxic activities of triorganotin(Ⅳ) complexes |
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| 作者姓名： | Hidayat Hussain Nazia Bibi Ahmed A-Harrasi Salman Siddiqi Shahana U.Kazmi Amin Badshah |
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| 作者单位： | Department of Chemistry,University of Paderborn 33098 Paderborn,Germany;Department of Btological Setences and Chemistry,College of Arts and Sciences,University of Nizwa,Oman;Immunology and Infectious Disease Research Laboratory Department of Microbiology,University of Karachi,Pakistan;Department of Molecular Mucrobilogy and Immunology Bloomberg School of Public Health,Johns Hopkins University,Baltimore,MD 21205,USA;Department of Biological Sciences and Chemistry,College of Arts and Sciences,University of Nizwa,Oman;Becton Dickinson Diagnostic Systems,Sparks,MD 21152.USA;Immunology and Infectious Disease Research Laboratory,Departnent of Microbiology,University of Karachi,Pakistan;Departmenf of Chenistry,Quaid-e-Azam University,Islamabad,45320,Pakistan |
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| 摘 要： | Five triorganotin（Ⅳ）（1-5） complexes of cinnamic acid.（Z）-2-acetamido-3-phenylacrylic acid,3-methylbut-2-enoic acid,and 2,2-diphenylacetic acid have been synthesized and characterized by 1H-13C-119Sn NMR,UV,and IR.The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin（IV） compounds.Five triorganotin（Ⅳ） complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator.The MICs were found to be 0.08 and 1.25μg/mL.
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| 关 键 词： | Triorganotin(Ⅳ) complexes Antituberculosis activity MICs Cytotoxicity |
| 收稿时间： | 9 November 2011 |
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