| Institution: | 1. NVision Imaging Technologies GmbH, Wolfgang-Paul-Strasse 2, 89081 Ulm, Germany;2. Nantes Université, CNRS, CEISAM UMR6230, 44000 Nantes, France;3. NVision Imaging Technologies GmbH, Wolfgang-Paul-Strasse 2, 89081 Ulm, Germany
Paul Scherrer Insititute, Forschungsstrasse 111, 5232 Villigen PSI, Switzerland;4. Paul Scherrer Insititute, Forschungsstrasse 111, 5232 Villigen PSI, Switzerland |
| Abstract: | The HYPNOESYS method (Hyperpolarized NOE System), which relies on the dissolution of optically polarized crystals, has recently emerged as a promising approach to enhance the sensitivity of NMR spectroscopy in the solution state. However, HYPNOESYS is a single-shot method that is not generally compatible with multidimensional NMR. Here we show that 2D NMR spectra can be obtained from HYPNOESYS-polarized samples, using single-scan acquisition methods. The approach is illustrated with a mixture of terpene molecules and a benchtop NMR spectrometer, paving the way to a sensitive, information-rich and affordable analytical method. |
