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The Future of (Radio)-Labeled Compounds in Research and Development within the Life Science Industry |
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| Authors: | Dr. Volker Derdau Dr. Charles S. Elmore Dr. Thomas Hartung Dr. Bruce McKillican Dr. Tom Mejuch Claudia Rosenbaum Prof. Dr. Christine Wiebe |
| Affiliation: | 1. Sanofi-Aventis Deutschland GmbH, Research & Development, Integrated Drug Discovery, Isotope Chemistry, Industriepark Höchst, G876, 65926 Frankfurt am Main, Germany;2. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Mölndal, Sweden;3. Pharma Research and Early Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland;4. Syngenta Crop Protection, LLC, North America Product Safety (retired), USA;5. BASF SE, Agricultural Solutions, Ludwigshafen, Germany |
| Abstract: | In this review the applications of isotopically labeled compounds are discussed and put into the context of their future impact in the life sciences. Especially discussing their use in the pharma and crop science industries to follow their fate in the environment, in vivo or in complex matrices to understand the potential harm of new chemical structures and to increase the safety of human society. |
| Keywords: | Crop Science Industry Isotope Science Metabolism Pharma Industry |