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Point-of-Care Testing for the Detection of MicroRNAs: Towards Liquid Biopsy on a Chip |
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| Authors: | Dr. Giulia Moro Dr. Chiara Dalle Fratte Prof. Dr. Nicola Normanno Prof. Dr. Federico Polo Prof. Dr. Stefano Cinti |
| Affiliation: | 1. Department of Pharmacy, University of Naples Federico II, Via Montesano 9, 80131 Naples, Italy These authors contributed equally to this work.;2. Department of Medical Biotechnology and Translational Medicine, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan “Statale”, Via Vanvitelli 32, 20133 Milan, Italy These authors contributed equally to this work.;3. Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori (IRCCS), Fondazione Pascale, Via Mariano Semmola, 53, 80131 Naples, Italy;4. Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Venice, Italy;5. Department of Pharmacy, University of Naples Federico II, Via Montesano 9, 80131 Naples, Italy |
| Abstract: | Point-of-care (PoC) testing is revolutionizing the healthcare sector improving patient care in daily hospital practice and allowing reaching even remote geographical areas. In the frame of cancer management, the design and validation of PoC enabling the non-invasive, rapid detection of cancer markers is urgently required to implement liquid biopsy in clinical practice. Therefore, focusing on stable blood-based markers with high-specificity, such as microRNAs, is of crucial importance. In this work, we highlight the potential impact of circulating microRNAs detection on cancer management and the crucial role of PoC testing devices, especially for low-income countries. A detailed discussion about the challenges that should be faced to promote the technological transfer and clinical use of these tools has been added, to provide the readers with a complete overview of potentialities and current limitations. |
| Keywords: | Biosensors Point-of-Care Testing Liquid Biopsy MiRNAs Clinical Trial |