Synthesis of 1-alkyl(aralkyl)-4-acyl-2-piperazinones |
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Authors: | Yu. S. Tsizin N. L. Sergovskaya S. A. Chernyak |
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Affiliation: | (1) E. I. Martsinovskii Institute of Medicinal Parasitology and Tropical Medicine, 119830 Moscow |
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Abstract: | 1-Alkyl(aralkyl)-4-acyl-2-piperazinones are formed in high yields during selective acylation of N-monosubstituted ethylenediamines by benzoyl and cyclohexylcarbonyl chlorides in the presence of pyridine hydrochloride and treatment of the reaction products with chloroacetyl chloride in the presence of potassium tert-butylate.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 514–517, April, 1986. |
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