Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines,corticosterone, glucose,creatine, and creatinine in rats |
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Authors: | Nicole R Herring Tori L Schaefer Peter H Tang Matthew R Skelton James P Lucot Gary A Gudelsky Charles V Vorhees Michael T Williams |
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Institution: | (1) Division of Neurology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA;(2) College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA;(3) Department of Pharmacology and Toxicology, Wright State University, Dayton, Ohio, USA |
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Abstract: | Background Methamphetamine (MA) use is a worldwide problem. Abusers can have cognitive deficits, monoamine reductions, and altered magnetic
resonance spectroscopy findings. Animal models have been used to investigate some of these effects, however many of these
experiments have not examined the impact of MA on the stress response. For example, numerous studies have demonstrated (+)-MA-induced
neurotoxicity and monoamine reductions, however the effects of MA on other markers that may play a role in neurotoxicity or
cell energetics such as glucose, corticosterone, and/or creatine have received less attention. In this experiment, the effects
of a neurotoxic regimen of (+)-MA (4 doses at 2 h intervals) on brain monoamines, neostriatal GFAP, plasma corticosterone,
creatinine, and glucose, and brain and muscle creatine were evaluated 1, 7, 24, and 72 h after the first dose. In order to
compare MA's effects with stress, animals were subjected to a forced swim test in a temporal pattern similar to MA administration
i.e., (30 min/session) 4 times at 2 h intervals]. |
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