Semi-synthetic polysaccharide sulfates as anticoagulant coatings for PET, 1--cellulose sulfate |
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| Authors: | Gericke Martin Doli?ka Ale? Stana Jan Liebert Tim Heinze Thomas Stana-Kleinschek Karin |
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| Institution: | 1. Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Centre of Excellence for Polysaccharide Research, Humboldtstra?e 10, D‐07743 Jena, Germany;2. Laboratory for Characterization and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, SI‐2000 Maribor, Slovenia;3. Faculty of Medicine, University of Maribor, Smetanova 17, SI‐2000 Maribor, Slovenia |
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| Abstract: | In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. |
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| Keywords: | anticoagulant coatings blood compatibility cellulose sulfates chitosan layer‐by‐layer assemblies |
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