Gram scale synthesis of the C(18)-C(34) fragment of amphidinolide C |
| |
Authors: | Morra Nicholas A Pagenkopf Brian L |
| |
Institution: | Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada. |
| |
Abstract: | The synthesis of the C(18)-C(34) fragment of amphidinolide C has been achieved via two routes, culminating in both the shortest (11 steps) and highest yielding (26% overall yield) approaches to this segment. The highly convergent approach will facilitate the synthesis of analogues, including the C(18)-C(29) fragment of amphidinolide F. Synthetic highlights include the selective methylation of a diyne, and the highly efficient use of a second generation cobalt catalyst in the Mukaiyama oxidative cyclization to form the trans-THF ring. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|