Indole derivatives

A new method for the synthesis of alkyl-substituted tetrahydro--carbolines has been developed which involves the cyclodehydration of 2-(2'-aminoisobutyl)indole and 2-(2 aminoethyl)indole with various aldehydes and ketones. The reduction with amalgamated zinc in hydrochloric acid of 2, 2-dimethyl-, 4, 4-dimethyl-, and 2, 2-dimethyl-4-phenyl-1, 2, 3, 4-tetrahydro--carbolines has been studied. The structure of the compounds obtained on reduction has been demonstrated.For part XXV, see 2].