Stochastic protein folding simulation in the three-dimensional HP-model |
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Authors: | Albrecht A A Skaliotis A Steinhöfel K |
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Institution: | University of Hertfordshire, Science & Technology Research Institute, Hatfield, Herts AL10 9AB, UK. |
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Abstract: | We present results from three-dimensional protein folding simulations in the HP-model on ten benchmark problems. The simulations are executed by a simulated annealing-based algorithm with a time-dependent cooling schedule. The neighbourhood relation is determined by the pull-move set. The results provide experimental evidence that the maximum depth D of local minima of the underlying energy landscape can be upper bounded by D
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Keywords: | Protein folding HP-model Landscape analysis Stochastic local search Simulated annealing |
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