Oxa-Pictet-Spengler reaction in water. Synthesis of some (±)-1-aryl-6,7-dimethoxyisochromans |
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| Authors: | Aamer Saeed |
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| Affiliation: | Department of Chemistry, Quaid-I-Azam University, 45320 Islamabad, Pakistan |
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| Abstract: | An acid catalyzed oxa-Pictet-Spengler reaction ‘on water’ leading to the synthesis of a variety of 1-aryl-6,7-dimethoxyisochromans is described. The aqueous chemistry is a much cleaner, efficient, cheaper and simple method for synthesis. The scope of reactions was extended to thia-Pictet-Spengler reaction to afford the some isothiochromans. |
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| Keywords: | Oxa-Pictet-Spengler reaction In water l-Aryl-6,7-dimethoxyisochromans Isothiochromans |
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