Enantioselective synthesis of the phosphate esters of the immunosuppressive lipid FTY720 |
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| Authors: | Xuequan Lu |
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| Affiliation: | Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, NY 11367-1597, USA |
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| Abstract: | The enantiomers of FTY720-phosphate (3) were synthesized via 2-methylene-4-(4-octylphenyl)butan-1-ol (7), 2,3-epoxy alcohol 8, and Δ2-oxazoline 10. These compounds have potential use in the treatment of autoimmune diseases and prevention of kidney transplant rejection. |
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